FOR KIM WOODS ONLY
Tabitha25ASSIGNMENT 1
Structure of DNA
Using the South University Online Library or the Internet, research DNA sequencing.
Based on your research, complete the following discussions:
· DNA sequencing has become a valuable tool in many areas of science, including forensic medicine and biological research. In relation to this, answer the following questions.
· Describe the steps by which DNA sequencing is performed.
· Describe, using at least one example, of how DNA sequencing has become a valuable tool in forensic medicine and/or biological research.
· What are the steps involved and the enzymes used in DNA replication? In your opinion, can a disorder result from the malfunction of any enzyme used during DNA replication? If yes, identify any one disorder and explain how it is caused. If no, why?
· Since one transcription factor can control multiple genes, mutations in transcription factors can have long-reaching effects.
· Can a disease result from a mutation in a transcription factor? If so, provide at least one example, naming the transcription factor, the mutation, and the congenital defect that arises.
ASSIGNMENT 2
Protein Translation
Complete the following discussions:
· Write a DNA sequence that will encode for at least five amino acids. Change three different bases separately (either by addition or deletion) and write the corresponding amino acid sequences that result from these modifications.
· Which genetic disorder (other than Alzheimer's disease, familial amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, Lewy body dementia, and prion disorders) results from protein misfolding? How does protein misfolding result in the onset of the disorder? In your opinion, is there sufficient current research on drugs or treatment for your chosen disorder?
· Using the South University Online Library and the Internet, search and describe a genetic disorder (other than α-thalassemia mental retardation syndrome, immunodeficiency–centromeric instability–facial anomalies [ICF] syndrome, Rett syndrome, and Rubinstein-Taybi syndrome) that results from aberrant chromatin remodeling. Does the disorder result from adding or deleting acetyl, methyl, or phosphate groups? Explain. Does the abnormal chromatin remodeling affect other genes?
· Using the South University Online Library and the Internet, search and describe a genetic disorder that results from aberrant gene splicing. How does alternative splicing affect the disorder? Where in the gene does the aberrant splicing occur?
From your course textbook Human genetics: Concepts and applications , read the following chapters:
· Overview of genetics
· Cells
Click here to access your Case Workbook for Human Genetics